The Research Technologist II – Pain Behavioral Pharmacologist performs functional assays to evaluate Aptinyx NMDA receptor modulator compounds’ efficacy and mechanism of efficacy in alleviating pain. The position requires the technologist to be able to work with the pain team to design and complete experiments in pain and potentially other behavioral pharmacology areas. This will include determining dose levels, regimes and timelines for experiments, completing pain surgeries, measuring pain responses, collecting, compiling and analyzing data. This requires knowledge of the pain area, with particular emphasis on neuropathic pain, and also a practical understanding of related scientific techniques.
Following are the essential functions of the role:
- Work as part of a team to perform pain related studies using rodent models (rat, mouse). These studies include chemical-induced systemic neuropathy, chemical-induced peripheral pain, and surgery-induced peripheral nerve injury.
- Be familiar with the functional assessment of pain i.e mechanical, thermal or spontaneous models of pain assessment.
- As opportunities and needs arise, participate in animal behavioral studies outside of neuropathic pain, including learning and memory studies, safety pharmacology studies, etc.
- Perform dosing calculations and prepare test compounds for each experiment.
- Administer test or control compounds to rodents through multiple potential routes of administration (oral gavage, intravenous, intraperitoneal, subcutaneous).
- Able to perform peripheral nerve injury surgeries.
- Able to run PK studies collecting blood and tissue.
- Able to complete dissections and collect tissues for protein analysis
- Set-up, operate, and maintain standard lab equipment to record detailed observation and measurements.
- Maintain detailed laboratory notebooks.
- Data analysis, statistical analysis and reporting of experiment results.
- Perform quality control checks / reviews of own and colleagues’ data, analysis and results.
- Maintain tight control of data at all points along experimental process.
- Keep appropriate databases updated (compound logs, results database, experimental logs, etc.)
- Participate in weekly research team meetings; occasionally present experiment outcomes to research team.
- Contribute to experimental planning and design discussions.
- Follow established protocols, policies, procedures and regulations.
- Additional duties may be required at the discretion of supervisors.
Required Education and Experience:
- Bachelor’s degree with minimum of 3 years of relevant experience
- Experience running animal experiments relevant to neuropathic pain (e.g., spared nerve injury, chronic constriction injury, STZ-induced, chemotherapy-induced, etc.)
- Animal surgery experience
- Experience in laboratory mammal handling and euthanasia
- Experience dosing laboratory rodents
- Experience conducting behavioral studies independently
- Experience analyzing experimental data, running statistics and reporting experimental output
- Ability to contribute to experimental design and trouble-shooting process
- Experience working under established protocols, policies and procedures in an animal behavioral assessment setting
- Excellent interpersonal and organizational skills
- Strong communication and writing skills
Preference will be given to candidates who have the following:
- Master’s Degree in relevant scientific field
- Pharmaceutical industry experience
- Blood and tissue collection
- Experience running safety studies (e.g., rotorod, open-field, etc.)
- Experience running animal experiments relevant to learning and memory or psychiatry (e.g., Morris water maze, Novelty object recognition, Porsolt forced-swim assay, etc.)