Careers

Thank you for your interest in Aptinyx.

The Aptinyx team has a strong track record of success and is both highly motivated and passionate about the discovery and development of promising, novel therapeutic candidates for brain and nervous system disorders with high unmet medical need.

At Aptinyx, we remain committed and responsive to our employees. Our company has a collaborative, collegial atmosphere and a leadership team that places high value on innovation. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Our offices are located in downtown Evanston Illinois with convenient access to both Metra and the CTA Purple Line.

Are you interested in learning more?

Aptinyx is currently seeking applicants for the following position(s):

Staff Accountant

The Staff Accountant will report to the Director of Finance and will be responsible for managing the Company’s spend by ensuring proper authorizations and validity of expenditures while maintaining strong controls around the process. This person will work closely with the various departments to understand their contractual spend and will accrue and report spending to management. In addition, the Staff Accountant will assist in the monthly close process and the external quarterly reporting.

Essential Functions (For consideration, a resume must accompany your response to this posting) :

  • Play an active role in driving the month-end close and financial reporting process.
  • Participate in annual financial statement audit and quarterly reviews.
  • Establish and/or maintain supporting schedules or information for tax filings and other government reporting (e.g. R&D credits, annual reports, sales & use taxes, VAT returns, economic census) as required.
  • Reconcile balance sheet accounts with adequate support.
  • Generate standard and customized reports for management and department heads.
  • Control the entire AP process from matching POs with invoices to vouchering and creating weekly payment runs.
  • Work with the appropriate individual in the business to reconcile differences in purchase orders and invoice pricing.
  • Respond to vendor inquiries regarding payment status, and reconcile vendor statements to the company’s records.
  • Record all AP activity, including payroll-related activity, and required accruals during the month-end closing process.
  • Maintain any add-on software as needed to support a paperless environment and proper workflow and approval.
  • Ensure adequate controls are in place, including approvals in accordance with the Company’s delegation of authority, and ensure invoices are moving through the process in a timely manner to facilitate on-time payment.
  • Implement and manage internal tracking system to ensure all Finance and Accounting related processes and policies are documented and reflect current practice; partner with team members and other company staff to develop and update written documentation.

REQUIRED EDUCATION:

  • Bachelor’s Degree in accounting

REQUIRED SKILLS AND EXPERIENCE:

  • A minimum of three years of experience in accounting, auditing or accounts payable.
  • Demonstrated problem solving abilities.
  • Experience working with accounting software such as QuickBooks, Great Plains, etc.
  • Excellent oral, written and interpersonal communication skills.
  • Demonstrated strong organizational skills with the ability to manage multiple responsibilities with a high degree of self-motivation.

PREFERRED EDUCATION, SKILLS AND EXPERIENCE:

  • CPA
  • Masters Degree
  • Pharmaceutical industry experience – specifically supporting Research and Development / Clinical functions

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com. Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training. Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Research Technologist II - Discovery Science

The Research Technologist II will follow established procedures and protocols under the general supervision of a research scientist. Work requires advanced knowledge of good laboratory practices in conducting standard scientific techniques. Tasked with cell culture (immortalized cell lines, dissociated cell culture, and explant culture),  tissue dissections, transfection of plasmids, and receptor trafficking assays. Performs research and/or development in collaboration with others for projects yet can function at a high level independently. Makes detailed observations, analyzes data and interprets results. Investigates, creates and develops new methods and technologies for project advancement. Maintains high level of professional expertise through familiarity with scientific literature. May participate in scientific conferences and contribute to scientific journals. Is capable of initiating scientific design and conducting own experiments.

Essential Functions (For consideration, a resume and a cover letter must accompany your response to this posting) :

  • Works independently as part of the Discovery Team to create and manage a core tissue culture laboratory.
  • Tasked with tissue dissections, cell culture (immortalized cell lines, dissociated cell culture, and explant culture), transfection of plasmids, and receptor trafficking assays.
  • Executes research experiments in accordance with laboratory and safety protocols.
  • Handles and disposes of hazardous and non-hazardous materials in accordance with safety protocols.
  • Identifies and presents opportunities to management regarding innovative techniques including experimental design and execution.
  • Leverages years of laboratory experience to identify opportunities for more efficient processes/procedures and presents those opportunities to management.
  • Contributes to scientific posters and publications.
  • Monitors lab supply inventories, making all stock solutions, and compiling orders for needed supplies.
  • Sets-up, operates and maintains standard lab equipment, records detailed observations and measurements, and presents those findings in weekly meetings.
  • Contributes to experimental planning and design.
  • Maintains high level of professional expertise through familiarity with scientific literature.
  • Additional duties may be required at the discretion of Research Scientist.

REQUIRED EDUCATION:

  • Bachelor’s degree in biochemistry, chemistry or cell and molecular biology

REQUIRED SKILLS AND EXPERIENCE:

  • A minimum of three (3) years of laboratory research experience is required, with preference given to candidates with four or more years of experience.
  • A minimum of one (1) year of experience in the biotech or pharmaceutical industry.
  • Preference will be given to candidates who had a major role in designing and implementing research projects.
  • Demonstrated proficiency in the Microsoft Office suite of products
  • Experience with the following techniques is required: animal handling, cell culture, primary neuronal culture, transient and stable transfection.

PREFERRED EDUCATION, SKILLS, AND EXPERIENCE:

  • Master’s Degree in biochemistry, chemistry or cell and molecular biology
  • Four (4) years or more of laboratory research experience.
  • Experience in epifluorescence or confocal microscopy is a definite plus.

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com.

Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Executive Director, Regulatory Affairs

The Executive Director, Regulatory will direct and lead all Regulatory Affairs activities for the company. Incumbent will develop and implement regulatory strategies that ensure the advancement of Aptinyx’s development programs. Provides guidance and counsel to senior management, R&D and clinical project teams on regulatory and quality matters and ensures the timely preparation of organized and scientifically valid regulatory submissions. Confidently interacts with and represents the company to the appropriate regulatory agencies.

Essential Functions:

  • Provides technical guidance on regulatory requirements to company leadership and to project teams
  • Directs the preparation of regulatory submissions to US FDA including INDs
  • Anticipates regulatory obstacles and emerging issues throughout the pharmaceutical product development lifecycle and proactively develops solutions with other members of the project team
  • Ensures compliance to GXP’s and other regulatory agency requirements and company policies
  • Lead communicator with all regulatory agencies. Acts as the principal contact with FDA and attends all FDA conference calls and meetings
  • Manages pre-approval compliance activities
  • Formulates company procedures to respond to regulatory authority queries. Develops follow-up program to address audit findings and monitor ongoing vendor/supplier compliance
  • Reviews and approves change controls including manufacturing processes and procedures, analytical procedures, and related batch records/testing SOP’s; assures appropriate reports are issued, approved, and implemented
  • Contributes to project teams providing regulatory expertise and guidance on regulatory matters
  • Budgetary responsibility for Regulatory Affairs. Prepares department budgets and identifies appropriate external resources as needed
  • Manages, and maintains appropriate policies and procedures to ensure regulatory compliance, including QSRs, GMPs, and ISO regulations
  • Identifies, assesses and incorporates best demonstrated industry practices to assure regulatory compliance with all FDA requirements
  • Develops and conducts training for Aptinyx employees, as necessary
  • Recognizes need for investigation due to deviation from written procedures, conducts investigation into non-conformance incidents/deviations and recommends disposition of the affected component

REQUIRED EDUCATION:
Master’s degree life sciences

REQUIRED SKILLS AND EXPERIENCE:

  • Minimum of 15 years of experience in regulatory and quality assurance within the biotech or pharmaceutical industry and at least 10 years of relevant North American and Global Regulatory experience
  • Track record of successful interaction with the regulatory agencies, as demonstrated by timely submissions and approvals of pharmaceutical/biotech compounds
  • Experience in regulatory affairs of outside the US, including in support of Phase 2 and 3 clinical development
  • Experience in a successful leadership role in developing and managing a team capable of developing and registering candidate drugs through to marketing approval
  • Acute sense of ethics and ability to work in a highly regulated environment
  • Excellent knowledge of US regulatory requirements
  • Track record of outstanding accomplishments with regulatory agencies, specifically with the FDA and international regulatory authorities
  • Experience in actively participating in a due diligence evaluation
  • Excellent understanding of the drug development process
  • Ability to build effective relationships with health authorities as well as with internal stakeholders and employees

PREFERRED EDUCATION, SKILLS AND EXPERIENCE:

  • PhD in life sciences
  • Experience in the CNS therapeutic area
  • Experience managing a quality function (GMP, GCP, GLP)

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com.

Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Associate Director, Clinical Quality Assurance

The Associate Director, Clinical Quality Assurance is responsible for leading, developing, and managing all aspects of Clinical Quality Assurance (CQA) initiatives and training programs within Aptinyx to ensure all GCP-related activities are conducted according to appropriate internal and external quality standards and proper governing quality as regulated by the FDA and other relevant authorities.

 

Essential Functions:

  • Leads and directs the implementation of CQA policies and procedures to ensure cohesive and consistent quality plans are executed
  • Develops and maintains CQA processes and audit activities internally within company facilities and externally with third party suppliers/external vendors to ensure each operate in accordance with all relevant regulatory standards and remain compliant and held accountable to such standards
  • Oversees the monitoring of clinical operations for GCP and SOP compliance
  • Identifies potential areas of CQA compliance vulnerability and risk; develops and implements corrective action plans for resolution to ensure conformity with regulatory commitments and regulations
  • Acts as primary lead during CQA-related inspections; prepares facilities and staff for successful inspections and product approvals by relevant regulatory agencies
  • Establishes and promotes a culture of compliance, adherence to processes, and documentation to ensure successful clinical research and operations
  • Leads the development of company training programs for GCP-related procedures, practices and system requirements
  • Provides metrics on a periodic basis to update senior leadership of the operation and progress of clinical quality and compliance efforts
  • Develops and manages department budget
  • Performs audits across study sites to ensure compliance to include pre-audit preparation to ensure successful outcome; evaluate and follow up on the appropriateness and completeness of corrective actions plans
  • Responsible for complaint handling system, including procedures, investigations, and responses
  • Assists with regulatory submissions
  • Remains current with CQA management trends; reviews and interprets new regulations, and ensures that quality systems evolve appropriately
  • Collaborates with clinical team to ensure compliant, efficient and effective communication, processes and procedures
  • Participates and represents CQA in project meetings and discussions as needed

REQUIRED EDUCATION:

  • Bachelor’s degree in life sciences or relevant field

REQUIRED SKILLS AND EXPERIENCE:

  • A minimum of eight years of relevant industry experience in quality assurance
  • A minimum of eight years of GCP auditing/compliance experience
  • Strong working knowledge of applicable regulations, guidelines, and industry standards, GCP guidelines, FDA, EMA and other international quality systems regulations and standards is required
  • Knowledge of pharmaceutical/biotechnology process and auditing practices
  • Successfully executed efforts to drive efficiency in Clinical Quality operations
  • Experience in establishing CQA standards with respect to clinical research and operations
  • Direct experience with interacting with US regulatory authorities for inspections
  • Experience managing third party contracts

PREFERRED EDUCATION, SKILLS AND EXPERIENCE:

  • Master’s Degree
  • PhD
  • Start-up experience

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com.

Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Research Technologist I - Behavioral Pharmacology

Position Summary

The Research Technologist – Behavioral Pharmacology plays an important role on the behavioral team, responsible for screening and characterizing Aptinyx compounds through in vivo preclinical studies. This role conducts tests and procedures, sets up and operates equipment, records observations and measurements and collects, compiles and analyzes data. We are seeking someone with a strong understanding of core scientific and experimental techniques related to animal studies and experience working in a team setting.

Essential Functions

  • Work as part of a team to perform behavioral pharmacology studies using rodent models (rat, mouse).
  • Perform dosing calculations and prepare test compounds appropriate dose for experiments.
  • Administer test or control compounds to rodents through multiple potential routes of administration (oral gavage, intravenous, intraperitoneal, subcutaneous).
  • Conduct multiple types of behavioral tests under pre-defined protocols with limited oversight, potentially including assays related to learning and memory, fear conditioning, traumatic brain injury, etc., working both independently and as part of a team.
  • Assist with animal surgeries as well as blood and tissue collection for microdissection and pharmacokinetic experiments.
  • Score behaviors across multiple behavioral models using manual scoring techniques or through the use of scoring / tracking software (e.g,. Noldus EthoVision, MedPC V) under established protocols.
  • Set-up, operate and maintain standard lab equipment to record detailed observation and measurements.
  • Maintain detailed laboratory notebooks.
  • Data analysis, statistical analysis and reporting of experiment results (e.g., internal reports).
  • Perform quality control checks / reviews of own and colleagues’ data, analysis and results.
  • Maintain tight control of data at all points along experimental process.
  • Keep appropriate databases updated (compound logs, results database, experimental logs, etc.)
  • Participate in weekly research team meetings; present experiment outcomes to research team.
  • Contribute to experimental planning and design discussions.
  • Follow established protocols, policies, procedures and regulations.
  • Additional duties may be required at the discretion of supervisors.

REQUIRED EDUCATION:

Bachelor’s degree in relevant scientific field

REQUIRED SKILLS AND EXPERIENCE:

  • A minimum of three (3) years of behavioral pharmacology experience required
  • Strong communication and writing skills
  • Highly organized
  • Experience in laboratory mammal handling and euthanasia
  • Experience dosing laboratory rodents
  • Experience conducting behavioral studies independently and as part of a team
  • Experience analyzing experimental data, running statistics and reporting experimental output
  • Ability to contribute to experimental design and trouble-shooting process
  • Experience working under established protocols, policies and procedures in an animal behavioral assessment setting

PREFERRED EDUCATION, SKILLS AND EXPERIENCE:

  • Master’s Degree in relevant scientific field
  • Pharmaceutical industry experience
  • Animal surgery experience
  • Blood and tissue collection
  • Experience running safety studies (e.g., rotorod, open-field, etc.)
  • Experience running animal experiments relevant to learning and memory or psychiatry (e.g., Morris water maze, Novelty object recognition, Porsolt forced-swim assay, etc.)
  • Experience with relevant software (CleverSys, MedPC V, EthoVision)

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com.

Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Director, Translational Science

Position Summary

The Director, Translational Science will develop and direct research and development activities for the Company’s  products, with a focus on translating non-human in-vivo research to meaningful outcomes for patients.  This role will report into the Vice President of Research and will direct all in-vivo efficacy studies for the Research team, including behavioral pharmacological studies and electrophysiological studies, relevant to screening compounds as well as evaluating identified leads.

We are seeking someone with a strong scientific background and team management experience to use both in-house and outsourced in-vivo studies to facilitate progression of compounds from screening through preclinical development and enable selection of clinical trial dose level, treatment paradigm and relevant endpoints. He or she will be responsible for managing protocol design, execution, interpretation and publication.

This role will work closely with senior leadership to develop research strategies, translate these strategies into priorities and operational goals and facilitate execution of goals using in-house and outsourced resources.

Essential Functions

Research Strategy:

  • Works with senior Research and Clinical department leadership to develop strategies to ensure effective achievement of scientific objectives.
    • Responsible for sourcing and aligning in-house and outsourced resources to meet company needs under personnel and budgetary constraints.
    • Identifies unique research tools, cellular and animal models that could provide translational data to help inform indication selection and clinical trial design.
    • Develops deep understanding of specific indications of interest.
  • Provides scientific leadership in the area on translational science enabling decisions on project progression and early development.
  • Establishes early key opinion leader buy-in to preclinical projects and likely translatability to clinical studies.
  • Represents Aptinyx as a research liaison and subject matter expert in meetings with key alliance partners.
  • Organizes and chairs sessions at technical meetings; presents papers; primary author or key contributor on major reports, products, papers, presentations and peer reviewed journals.
  • Works with senior leadership to plan publication strategy related to lead compound efficacy studies. Identifies relevant studies for publication inclusion and manages execution of studies.
  • Attends symposia and other relevant conferences to stay abreast of latest research in high-priority indications and to interact with external collaborators.

Outsourced Research:

  • Identifies and develops academic investigators/institutions as well as contract research organizations for potential collaborations and work products.
  • Manages operational aspects of outsourced research activities. Provides contract management support of sponsored research agreements, material transfer agreements, service agreements, and license agreements. Ensures compliance with stated deliverables, overseeign study execution and finalizing reports.
  • Travels to collaboration sites to monitor activities and build effective working relationships.
  • Works closely with Clinical, Drug Development, Finance and other stakeholders to ensure the appropriate flow of information from collaborations.

In-house Research:

  • Selects, develops and evaluates in-vivo Research team to ensure the efficient operation of the function and provides intensive mentoring and training of research staff.
  • Utilizes project planning techniques to plan, develop and coordinate lab operations, projects and resources. Maintains project plans and updates those plans as needed.
  • Provides ideas to improve efficiency.

REQUIRED EDUCATION:

  • Ph.D. in neuroscience, biology, pharmacology or a related scientific discipline with a focus on CNS

REQUIRED SKILLS AND EXPERIENCE:

  • A minimum of 10 years of related experience
  • A minimum of 4 years of direct management experience within the pharmaceutical industry, including managing laboratory staff
  • Multidisciplinary in vivo pharmacologist/biologist with complementary technical experience, such as electrophysiology, behavioral neuroscience, neurochemistry, etc.
  • Substantial knowledge of CNS drug discovery and development with direct leadership experience
  • Experience with in vivo models in multiple species (rodent and non-rodent), as well as correlating in vitro with in vivo models.
  • Experience managing research vendors and collaborators, such as contract research organization and academic laboratories, particularly related to in-vivo studies
  • Demonstrated success in technical proficiency, scientific creativity, collaboration with others and independent thought
  • Highly organized; ability to multitask and to execute on multiple diverse projects simultaneously
  • Proficient in Microsoft Excel, PowerPoint, GraphPad Prism, Spotfire and / or other relevant software platforms

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com.

Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Senior Medical Director

Position Summary

The Senior Medical Director is responsible for directing clinical research activities within the PTSD program.  This position manages the PTSD program to successful registration and approval of pipeline projects in full compliance with regulatory guidelines.   In addition, this role will engage the external healthcare community to communicate the company’s product(s) and attributes, specifically in the PTSD arena.

Essential Functions

  • Provides clinical input, including trial design, medical monitoring, and regulatory submission preparation, as well as managing the selection of clinical consultants and investigators.
  • Contributes significantly to clinical development protocols and programs. Reviews and refines the clinical development protocols and plans, and works with colleagues in other departments to ensure that the clinical goals for the company’s program are met.
  • Manages external consultants to expertly advance the company’s development program.
  • In conjunction with other relevant functional areas, develops the strategic development plan for compounds.
  • Assists in the hiring, recruiting and retention of key high caliber staff in support of the development project.
  • Collaborates with various business units upon request to provide medical expertise for the development of training materials, medical and sales training, regulatory review, life cycle management and opinion leader relationships.
  • Assists in the creation of clinical trial designs, synopses and protocols for the company’s clinical programs.
  • Partners with clinical team to ensure that all clinical trials have achievable goals and can be enrolled on the timelines proposed.
  • Monitors project deliverables from inception to completion and achieves high quality results which meet clinical end-points in a timely manner.
  • Collaborates with Safety Reporting disciplines to ensure timely and accurate adverse event reporting and follow-up.
  • Collaborates with Regulatory Affairs to prepare for the company’s submissions, presentations, responses and guidance to the FDA or country specific regulatory authorities.
  • Leads interactions with regulatory authorities, when requested.
  • Oversees the staff assigned to specific clinical studies including site selection, CRF design, study document preparation, study initiation, data collection and reporting.
  • Provision of advice and rulings about inclusion and exclusion criteria questions from sites.

REQUIRED EDUCATION:

  • Medical Degree (Psychiatry)

REQUIRED SKILLS AND EXPERIENCE:

    • Minimum of 10 years of clinical development experience in the pharmaceutical, biotechnology or CRO industries with
    • Specific experience managing clinical trials in PTSD or related indications
    • Experience working on clinical trials that led to the filing and FDA interactions for at least one NDA
    • Experience with the US FDA and EMEA, including pre-NDA, NDA and advisory committee interactions
    • Substantial experience networking within the CNS-related disease community preferred
    • Expertise in the areas of clinical development, clinical operations, and strategic planning, specifically management of clinical trial operations
    • Demonstrated experience managing and mentoring clinical team members
    • Demonstrated knowledge of clinical pharmaceutical standards, ICH/GCP guidelines, and regulatory compliance
    • Must have extensive experience managing CROs, central laboratories, and other clinical study vendors
    • Must have a working knowledge of data management, data review and analysis, and drug safety and pharmacovigilence
    • Effective leadership skills and proven ability to foster team productivity and cohesiveness
    • Excellent communication/interaction skills and experience in a dynamic and growing organization
    • Ability to travel to investigator sites, investigator meetings, and scientific/medical meetings

PREFERRED EDUCATION, SKILLS AND EXPERIENCE:

  • PhD or PharmD in addition to Medical Degree
  • Master’s Degree in Business
  • Prior clinical trials experience and participation on clinical programs that have been filed for registration with the FDA is preferred

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com.

Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

Research Technologist II - Molecular Pharmacology

Position Summary

The Research Technologist II, Molecular Pharmacology will perform research to characterize and prioritize Aptinyx compounds and explore mechanistic underpinnings of compound efficacy in diseases of the brain. This person will participate in designing experiments, completing experiments, organizing and analyzing results and maintaining laboratory data and notebooks. They will work collaboratively with other researchers. Methods utilized to include cell culture, molecular, and cell biologic techniques. This person will also provide support for animal studies.

Essential Functions

  • Designs and executes target-based assays to identify hits/lead candidates and validate compound mechanism of action
  • Follow established protocols, policies, procedures and regulations.
  • Develops new protocols and analyzes and troubleshoots existing protocols and data obtained from individual experiments and recommends alternatives and suggestions to improve processes, validity and/or accuracy.
  • Conducts rigorous data analysis, prepares charts & graphs for presentations and communicates findings effectively to multidisciplinary team members and management
  • Maintains detailed records of results and generates clear well-written reports
  • Perform quality control checks / reviews of own and colleagues’ data, analysis and results.
  • Keep appropriate databases updated (compound logs, results database, experimental logs, etc.)
  • Performs scientific literature searches in support of research.
  • A fully functioning level of understanding in the following highlighted skills is required:
    • Molecular Biology
      • DNA, RNA, Protein isolation, purification and expression
      • Southern, Northern, Western blotting
      • PCR, RT-PCR
      • In situ hybridization
      • Immunohistochemistry
    • Cellular Biology
      • Cell culture, cell isolation, cryogenic storage
      • Functional studies
      • Aseptic technique
    • Histology
      • Tissue fixation/processing: embedding, preparation of blocks and sectioning, staining
      • Microscopy
  • Provide support for animal studies including animal dosing (IV, IP, PO, SC) and dissections.

REQUIRED EDUCATION:

  • Bachelor’s degree

REQUIRED SKILLS AND EXPERIENCE:

  • A minimum of four (4) years of laboratory research experience.
  • Attention to detail and accurate record keeping.
  • Ability to work independently and in a team environment.
  • Highly organized.
  • Ability to prioritize.
  • Be able to follow Standard Operating Procedures (SOPs).
  • Proven track record of contributing to successful and innovative drug development projects.
  • Highly experienced in preclinical high through-put assay development.

PREFERRED EDUCATION, SKILLS AND EXPERIENCE:

  • Master’s Degree in biochemistry, chemistry or cell and molecular biology
  • A minimum of two (2) years of experience in the biotech / pharmaceutical industry.

No agencies please.

Aptinyx is committed and responsive to our employees. We offer an engaging work environment, challenging work assignments, and competitive compensation and benefits. Aptinyx is conveniently located in downtown Evanston next to Metra and CTA stations. If you are interested in learning more, please visit our website at www.aptinyx.com.

Aptinyx provides equal employment opportunities (EEO) to all employees and applicants for employment without regard to race, color, religion, sex, national origin, age, disability or genetics. In addition to federal law requirements, Aptinyx complies with applicable state and local laws governing nondiscrimination in employment in every location in which the company has facilities. This policy applies to all terms and conditions of employment, including recruiting, hiring, placement, promotion, termination, layoff, recall, transfer, leaves of absence, compensation and training.

Aptinyx expressly prohibits any form of workplace harassment based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status.

  • Thank you for your interest in Aptinyx. Prior to submitting your resume, please take a few moments to provide us with the following information.

    *Required Field

  • Don’t forget to attach your resume prior to submitting this form. If you have difficulty submitting your resume using the links below, feel free to send your resume to HR@aptinyx.com. Thank you again for your interest in Aptinyx.
  • Accepted file types: doc, docx, pdf.
  • Accepted file types: doc, docx, pdf.
  • Aptinyx Inc. is an equal opportunity employer and does not discriminate against otherwise qualified applicants on the basis of race, color, creed, religion, ancestry, age, sex, marital status, sexual orientation, national origin, disability or handicap, veteran status or genetics.

    Note to Employment Agencies: Please do not forward any agency resumes. The company will not be responsible for any fees related to resumes that are unsolicited.